Wu Lab

Our lab's research is focused on the development and translation of new technologies for Quantitative MRI-Guided Therapy, which includes detection/characterization, treatment planning, interventional guidance, and treatment monitoring of cancer.

Research Directions and Specific Projects

Quantitative Prostate MRI
- Quantitative T2 and ADC mapping in prostate cancer
- High-resolution diffusion-weighted MRI
- Integrated diagnostics for prostate cancer (collaboration with Urology and Pathology)

Quantitative Liver MRI
- Free-breathing quantitative MRI of liver fat fraction and R2*
- MRI and MRE of pediatric liver disease (collaboration with Pediatrics)

Quantitative Placenta MRI
- Free-breathing quantitative MRI of placental R2* (collaboration with Pediatrics and Ob/Gyn)

MRI-Guided Interventions
- Real-time non-Cartesian MRI
- Real-time MR temperature mapping
- MRI-guided targeted biopsy and focal ablation
- Artificial intelligence for procedural guidance
- MRI-compatible robotic systems (collaboration with MAC lab)
- Precision MRI-guided nano-theranostics (collaboration with Zink lab | news)

Selected Recent Publications

Zhang L, Armstrong T, Li X, Wu HH. A Variable Flip Angle Golden‐Angle‐Ordered 3D Stack‐of‐Radial MRI Technique for Simultaneous Proton Resonant Frequency Shift and T1‐Based Thermometry. Magnetic Resonance in Medicine 2019.

Armstrong T, Ly KV, Ghahremani S, Calkins KL, Wu HH. Free-Breathing 3-D Quantification of Infant Body Composition and Hepatic Fat using a Stack-of-Radial Magnetic Resonance Imaging Technique. Pediatric Radiology 2019.

Armstrong T, Liu D, Martin T, Masamed R, Janzen C, Wong C, Chanlaw T, Devaskar SU, Sung K, Wu HH. 3D R2* Mapping of the Placenta During Early Gestation Using Free-Breathing Multiecho Stack-of-Radial MRI at 3T. Journal of Magnetic Resonance Imaging 2018.

Wu HH, Priester A, Khoshnoodi P, Zhang Z, Shakeri S, Afshari Mirak S, Asvadi NH, Ahuja P, Sung K, Natarajan S, Sisk A, Reiter R, Raman S, Enzmann D. A System Using Patient-Specific 3D-Printed Molds to Spatially Align In Vivo MRI with Ex Vivo MRI and Whole-Mount Histopathology for Prostate Cancer Research. Journal of Magnetic Resonance Imaging 2018. Prostate mold resources

Armstrong T, Ly KV, Murthy S, Ghahremani S, Kim GHJ, Calkins KL, Wu HH. Free-Breathing Quantification of Hepatic Fat in Healthy and NAFLD Children Using a Multiecho 3D Stack-of-Radial MRI Technique. Pediatric Radiology 2018; 48:941-953.

Armstrong T, Dregely I, Stemmer A, Han F, Natsuaki Y, Sung K, Wu HH. Free-Breathing Liver Fat Quantification using a Multiecho 3D Stack-of-Radial Technique. Magnetic Resonance in Medicine 2018; 79(1):370-382.

Simonelli J, Lee Y, Mikaiel S, Chen C, Li X, Sung K, Lu D, Wu HH, Tsao TC. An MR-Compatible Stage for Respiratory Motion Emulation. International Federation of Automatic Control (IFAC) PapersOnLine 2017; 50(1):6073-6078.

Rangwala N, Dregely I, Wu HH, Sung K. Optimization and Evaluation of Reference Region Variable Flip Angle (RR-VFA) B1+ and T1 Mapping in the Prostate at 3T. Journal of Magnetic Resonance Imaging 2017; 45(3):751-760.

Dregely I, Margolis D, Sung K, Zhou Z, Rangwala N, Raman S, Wu HH. Rapid Quantitative T2 Mapping of the Prostate using 3D DESS MRI at 3 T. Magnetic Resonance in Medicine 2016; 76(6):1720-1729.  

Lab Members

Holden H. Wu, Ph.D.

Postdoctoral Scholars
Le Zhang, Ph.D.
Tess Armstrong, Ph.D.

Graduate Students
Xinzhou Li, B.S.
Zhaohuan Zhang, B.S.
Shu-Fu Shih, M.S.
Sevgi Kafali, M.S.

Staff Research Associate
Benjamin Azul

Administrative Staff
Heather Wilbur

Previous Members
Isabel Dregely, Ph.D. (postdoc, 2013-2015; now at King's College London)
Novena Rangwala, Ph.D. (postdoc, 2013-2016, jointly with Dr. Kyung Sung; now at GE Healthcare)
Samantha Mikaiel, M.S. (graduate student, 2014-2018; now at Vanguard)
M. Wasil Wahi-Anwar, B.S. (graduate student, 2014)
Matthew Quesada (undergraduate student, Fall 2014)
Chengyang Song, B.S. (visiting graduate student, Fall 2015)
Tongxin Chen (visiting undergraduate student, Summer 2016)
Yu Wang (visiting undergraduate student, Summer 2017)
Cass Wong, B.S. (undergraduate student, 2017)
Michael Lauria, B.S. (lab rotation, Fall 2017)
Chang Gao, B.S. (lab rotation, Fall 2017)
Arash Safavi, M.S. (staff research associate, 2017-2018)

We are looking for new postdocs and graduate students!

Honors and Awards

ISMRM W. S. Moore Young Investigator Award Finalist - Tess Armstrong (2019)
ISMRM Magna Cum Laude Award - Tess Armstrong (2019)
ISMRM Summa Cum Laude Award - Xinzhou Li (2019)
UCLA PBM Dr. Moses A. Greenfield Award - Tess Armstrong (2018)
ISMRM Summa Cum Laude Award - Tess Armstrong (2018)
ISMRM Magna Cum Laude Award - Tess Armstrong (2018)
RSNA Trainee Research Prize - Tess Armstrong (2017) | news 
UCLA PBM Research Colloquium Best Oral Presentation Award - Samantha Mikaiel (2017)
ISMRM Summa Cum Laude Award - Tess Armstrong (2017)
UCLA Grad Slam Finalist - Samantha Mikaiel (2016)
ISMRM Magna Cum Laude Award - Tess Armstrong (2016)
ISMRM Magna Cum Laude Award - Tess Armstrong (2015)
NSF Graduate Research Fellowship - Samantha Mikaiel (2015-2018)
MRM Distinguished Reviewer - Holden Wu (2012-2018)